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The principal cytochrome P450 isoenzyme associated seems to become CYP2E1, with CYP1A2 and CYP3A4 as further pathways. Roughly 85% of an oral dose seems inside the urine in 24 hrs of administration, most since the glucuronide conjugate, with small amounts of other conjugates and unchanged drug.There are no common opioid tapering schedules which hav